This module has been designed to develop advanced knowledge of the nature and action of endogenous transmitters and exogenous drugs as they interact in the human nervous system. The module begins with an introduction to transmitter-receptor interaction and outlines the major characteristics of the chemical synapse, and nerves. It is then followed by an introduction to the brain environment, in particular its regulation and the role of glial cells. The role of neurotransmitters such as Acetycholine, Norepinephrine, Dopamine, GABA, Glutamate, Enkaphalin, and Serotonin, are subsequently investigated at the same level, as is the role of ion channels and the means to show their action eledctrophysiologically. Interaction of exogenous substances with these systems will form part of the delivery of the material. Disruption of the brain environment by disease will form a discussion base upon which integrated nature of transmitters and the cells of the CNS will be investigated. At the end of the module the student should be able to understand neurotransmitter interaction at the receptor and ion channel level, and the subsequent importance of these functions in the CNS of humans. In order to become familiar with the material presented in the lectures, students will need to engage in the literature surrounding each transmitter type, as well as brain environment and its control.

There is One piece of assessment for this module

An EXAM, 2hr, weighted at 100% and taken at the end of the module in the appropriate exam period.

Learning outcomes: 1, 2, 3, 4

Additional Assessment Details (including formative feedback / assessment):
Time will be made available for formative feedback activities during workshops.
Criteria relating to these assessments are available in the module handbook, and for the intranet-supported assignment on the server dedicated to this assessment type.

Rang and Dale's Pharmacology (6th edition). Editors Rang, Dale, Ritter and Flower. Published by Churchill Livingstone. (2015)

Lecture theatre with data projector, internet access. PC-based IT facilities, access to Blackboard. Library materials particularly the Journals: Trends in Neuroscience; Trends in Pharmacology; New Scientist; Science; Nature; Annual Reviews of the Neurosciences

1. Demonstrate knowledge of the function of the central nervous system
Knowledge and Understanding

2. Recognise and correctly demonstrate knowledge of neuronal transmission, in terms of ligands and receptors, and use of synaptic models to evaluate such interaction.
Enquiry
Knowledge and Understanding

3. Evaluate ideas and concepts relating to the neuronal environment.
Analysis
Reflection

The module uses a blend of face to face lectures and workshops supported by a VLE containing additional formative tasks and support materials. Lectures will be used to deliver subject specific information and tutor lead discussion on neurobiological topics relevant to that delivery. A range of multimedia support will be available via the VLE. The E-library and Faculty LRC will be used to support investigations into secondary and primary literature sources linked to the assessment.

This module involves independent self-directed study and guided reading before and after sessions using own notes and material available on the Blackboard course pages.