1. EXPLAIN THE MAJOR CONCEPTS OF MOLECULAR GENETICS DEVELOPED AND UNDERSTANDING OF THE KEY TECHNOLOGIES OF GENETIC ANALYSIS, GENETIC ENGINEERING AND MOLECULAR GENETICS Knowledge and Understanding

2. EVALUATE THE APPLICATION OF THE TECHNIQUES COVERED FOR THE DIAGNOSIS AND TREATMENT OF GENETIC DISEASE AND BE AWARE OF THE BROADER IMPORTANCE OF THE TECHNIQUES IN TERMS OF GENERAL APPLICATION
Analysis

3. OUTLINE EXPERIMENTAL STRATEGIES TOWARD A SPECIFIC GOAL USING THE TECHNOLOGY of DNA ANALYSIS; DNA EXTRACTION, RESTRICTION, GEL ELECTROPHORSIS, PCR, DNA SEQUENCING. COMMUNICATE EFFECTIVELY THE BACKGROUND AND OUTCOME OF TOPICS IN THIS MODULE Problem Solving
Communication

1 Written assignment 50% 3000
2 Test 50% 90 min

This module is designed to focus on the theory that underpins practice in Molecular genetics and genetic engineering. It will develop your critical thinking and experimental design skills both of which will contribute to your employability. Broadly, the module aims to develop the introductory genetics from Level 4 beyond the fundamentals, through level 5 and as a support to level 6 modules. The applications of molecular genetics to modern cell biology and including the basic tenets of genetic engineering, with particular emphasis towards human genetics and health as a major theme, but there are opportunities for consideration of how these methodologies apply to the study of animals including wildlife and plants. Application will be considered at all points. The content will include the architecture of the genome, karyotyping, recombination, linkage and mapping. Discussion of the mosaic structure of eukaryotic genes, leads to RNA splicing and the control of gene expression (regulatory elements, promoters, terminators), imprinting and epigenetics. The tools for genetic engineering and analysis, restriction enzymes, DNA ligase, vectors and gene libraries, their construction; genomic and cDNA libraries will be covered followed by the various methods of selecting individual genes from libraries. Nucleic acid hybridisation (northern and Southern blotting), DNA sequencing and the polymerase chain reaction will be covered in workshops as major techniques in DNA technology. Please note that all practical skills related to Molecular genetics and genetic engineering are part of the Applied Science module.

The module is comprised of lectures developing your knowledge and understanding of molecular genetics and genetic engineering including applications. Workshops examine through case-based learning which is student-led, examples of how these technologies can assist in our understanding of the fundamental control and development of all life on earth. You will be required to read advanced papers and articles, analyse data and interpret results.

Brown, T. A. 2010. Gene Cloning and DNA Analysis. 6th ed. Wiley-Blackwell
Brown, T. A. 2011. Introduction to Genetics: A Molecular Approach. Garland Science
Coico, R. and Sunshine, G. (2009) Immunology. John Wiley & Sons, Inc., Hoboken, New Jersey.
Lodish, H., Berk, A., Kaiser, C.A., Krieger, M. Scott, M.P., Bretscher, A., Ploegh, H. and Matsudaira, P.
(2008). Molecular Cell Biology. W.H. Freeman and Co., New York.
Alberts, B., Johnson, A., Lewis, J., Raff, M., Roberts, K. and Walter P. 6th ed. (2015). Molecular Biology of the Cell. Garland Science, New York.

Suitable rooming for group work and discussion. Full IT facilities including screen casting.

This module is designed to focus on the theory that underpins practice in Molecular genetics and genetic engineering. It will develop your critical thinking and experimental design skills both of which will contribute to your employability. Broadly, the module aims to develop the introductory genetics from your first year beyond the fundamentals, through your second and final years. The applications of molecular genetics to modern cell biology and including the basic tenets of genetic engineering, with particular emphasis towards human genetics and health as a major theme, but there are opportunities for consideration of how these methodologies apply to the study of animals including wildlife and plants. Application will be considered at all points. The content will include the architecture of the genome, karyotyping, recombination, linkage and mapping. Discussion of the mosaic structure of eukaryotic genes, leads to RNA splicing and the control of gene expression (regulatory elements, promoters, terminators), imprinting and epigenetics. The tools for genetic engineering and analysis, restriction enzymes, DNA ligase, vectors and gene libraries, their construction; genomic and cDNA libraries will be covered followed by the various methods of selecting individual genes from libraries. Nucleic acid hybridisation (northern and Southern blotting), DNA sequencing and the polymerase chain reaction will be covered in workshops as major techniques in DNA technology. Please note that all practical skills related to Molecular genetics and genetic engineering are part of the Applied Science module.