Module Descriptors
ADVANCED DNA PROFILING
BIOL60496
Key Facts
Health, Education, Policing and Sciences
Level 6
15 credits
Contact
Leader: Abdulrahman Oleiwi
Hours of Study
Scheduled Learning and Teaching Activities: 33
Independent Study Hours: 117
Total Learning Hours: 150
Assessment
- PORTFOLIO weighted at 50%
- EXAMINATION - UNSEEN IN EXAMINATION CONDITIONS weighted at 50%
Module Details
Learning Outcomes
1. DEMONSTRATE A SYSTEMIC UNDERSTANDING OF THE THEORY AND EXPERIMENTAL TECHNIQUESASSOCIATED WITH DNA PROFILING
Knowledge and Understanding
2. ANALYSE AND INTERPRET PROPERLY DATA PRODUCED BY THESE TECHNIQUES
Problem Solving
Application
3. CRITICALLY EVALUATE THE VALUE AND APPLICATION AND LIMITATIONS OF DNA PROFILING, MMITOCHONDRIAL AND Y CHROMOSOME ANALYSIS IN FORENSIC INVESTIGATIONS THEORETICALLY AND FFORM THE PRACTICAL WORK
Analysis
Enquiry
Reflection
4. COMMUNICATE EFFECTIVELY THE BACKGROUND AND OUTCOME OF EXPERIMENTAL WORK Communication
5. DEVELOP MANUAL AND TECHNICAL PROFICIENCY, GOOD LABORATORY PRACTICE, NUMERICAL COMPETENCE, ORGANISATION AND RIGOR IN LAB. WORK. MANAGEMENT AND PRESENTATION OF RESULTS AND CONCLUSIONS
Learning
Communication
Application
Knowledge and Understanding
2. ANALYSE AND INTERPRET PROPERLY DATA PRODUCED BY THESE TECHNIQUES
Problem Solving
Application
3. CRITICALLY EVALUATE THE VALUE AND APPLICATION AND LIMITATIONS OF DNA PROFILING, MMITOCHONDRIAL AND Y CHROMOSOME ANALYSIS IN FORENSIC INVESTIGATIONS THEORETICALLY AND FFORM THE PRACTICAL WORK
Analysis
Enquiry
Reflection
4. COMMUNICATE EFFECTIVELY THE BACKGROUND AND OUTCOME OF EXPERIMENTAL WORK Communication
5. DEVELOP MANUAL AND TECHNICAL PROFICIENCY, GOOD LABORATORY PRACTICE, NUMERICAL COMPETENCE, ORGANISATION AND RIGOR IN LAB. WORK. MANAGEMENT AND PRESENTATION OF RESULTS AND CONCLUSIONS
Learning
Communication
Application
Indicative Content
The module builds on molecular genetic work studied at level 2 where the fundamental knowledge and
understanding needed to discuss DNA profiling was developed. This module takes the material to a greater
depth, taking it to a level approaching that of a professional. There will be a detailed coverage of DNA
profiling from the collection of evidence to the interpretation and presentation of the data. Lectures will
give the scientific background to the techniques, the typing systems used (STR typing, mitochondrial
sequencing and the developing SNP analysis), when certain systems are applied rather than other ones,
the significance and interpretation of the results, DNA profiling databases, quality control and regulation.
Statistical interpretation of the evidence will be taken to a deeper level. Issue of data quality and
presentation of DNA evidence will be considered. Laboratory sessions will give practical experience of the
procedures from collection of samples to interpretation of results.
understanding needed to discuss DNA profiling was developed. This module takes the material to a greater
depth, taking it to a level approaching that of a professional. There will be a detailed coverage of DNA
profiling from the collection of evidence to the interpretation and presentation of the data. Lectures will
give the scientific background to the techniques, the typing systems used (STR typing, mitochondrial
sequencing and the developing SNP analysis), when certain systems are applied rather than other ones,
the significance and interpretation of the results, DNA profiling databases, quality control and regulation.
Statistical interpretation of the evidence will be taken to a deeper level. Issue of data quality and
presentation of DNA evidence will be considered. Laboratory sessions will give practical experience of the
procedures from collection of samples to interpretation of results.
Assessment Details
Students will be required to complete 2 pieces of summative assessment.
Portfolio of practical work and data analysis (50%), addressing outcomes 1 -6
Examination of 1 h (50%), addressing outcomes 1-3 and 5
Students will be provided with formative assessment and feedback via
practical sessions. This will be the final assessment for the module.
Portfolio of practical work and data analysis (50%), addressing outcomes 1 -6
Examination of 1 h (50%), addressing outcomes 1-3 and 5
Students will be provided with formative assessment and feedback via
practical sessions. This will be the final assessment for the module.
Learning Strategies
Over 11 weeks the module will include 11 hours of supervised laboratory sessions of which approximately 3 will be tutorials related to the practical being undertaken and analysis of data generated by it. 22 hours of lectures.
There will be 1176 hours of independent study involving data analysis and interpretation
There will be 1176 hours of independent study involving data analysis and interpretation
Texts
J M Butler (2013) Advanced Topics in Forensic DNA Typing - can be obtained at http://220.163.113.53/g2s/ewebeditor/uploadfile/20130416175005_315599781486.pdf
H.Mountain, (2016). “Analysis of deoxyribonucleic acid (DNA): DNA profiling” Chapter 6 in A.J.W. Jackson & J. Jackson “Forensic Science. 4rd ed”. Prentice Hall.
J.M.Butler (2009) Fundamentals of Forensic DNA Typing, Academic Press ISBN-10: 0123749999,
W.Goodwin, A. Linacre & Sibte Hadi (2010) “An introduction to forensic genetics.” 2nd ed.Wiley.
K. Inman & N. Rudin "An introduction to forensic DNA analysis"1996, CRC Press, New York.
ISBN 0-8493-8117-7
I.W.Evett & B.S. Weir "Interpreting DNA evidence" 1998, Sinauer Press.
H.Mountain, (2016). “Analysis of deoxyribonucleic acid (DNA): DNA profiling” Chapter 6 in A.J.W. Jackson & J. Jackson “Forensic Science. 4rd ed”. Prentice Hall.
J.M.Butler (2009) Fundamentals of Forensic DNA Typing, Academic Press ISBN-10: 0123749999,
W.Goodwin, A. Linacre & Sibte Hadi (2010) “An introduction to forensic genetics.” 2nd ed.Wiley.
K. Inman & N. Rudin "An introduction to forensic DNA analysis"1996, CRC Press, New York.
ISBN 0-8493-8117-7
I.W.Evett & B.S. Weir "Interpreting DNA evidence" 1998, Sinauer Press.
Resources
Well-appointed lecture room, appropriately equipped laboratory, well stocked library and
access to IT for tutorial work
Blackboard VLE
access to IT for tutorial work
Blackboard VLE
Special Admissions Requirements
Level 5 study of genetics in Molecular Genetics (BIOL50709) or DNA Profiling and Forensic Biology (FORE503170)
Web Descriptor
The module builds on molecular genetic work studied at level 2 where the fundamental knowledge and
understanding needed to discuss DNA profiling was developed. This module takes the material to a greater
depth, taking it to a level approaching that of a professional. There will be a detailed coverage of DNA
profiling from the collection of evidence to the interpretation and presentation of the data. Lectures will
give the scientific background to the techniques, the typing systems used (STR typing, mitochondrial
sequencing and the developing SNP analysis), when certain systems are applied rather than other ones,
the significance and interpretation of the results, DNA profiling databases, quality control and regulation.
Statistical interpretation of the evidence will be taken to a deeper level. Issue of data quality and
presentation of DNA evidence will be considered. Laboratory sessions will give practical experience of the
procedures from collection of samples to interpretation of results.
understanding needed to discuss DNA profiling was developed. This module takes the material to a greater
depth, taking it to a level approaching that of a professional. There will be a detailed coverage of DNA
profiling from the collection of evidence to the interpretation and presentation of the data. Lectures will
give the scientific background to the techniques, the typing systems used (STR typing, mitochondrial
sequencing and the developing SNP analysis), when certain systems are applied rather than other ones,
the significance and interpretation of the results, DNA profiling databases, quality control and regulation.
Statistical interpretation of the evidence will be taken to a deeper level. Issue of data quality and
presentation of DNA evidence will be considered. Laboratory sessions will give practical experience of the
procedures from collection of samples to interpretation of results.