Module Descriptors
DRUG FORMULATION AND DELIVERY
BIOL60649
Key Facts
Health, Education, Policing and Sciences
Level 6
15 credits
Contact
Leader: Steven Corden
Email: Steven.Corden1@staffs.ac.uk
Hours of Study
Scheduled Learning and Teaching Activities: 24
Independent Study Hours: 126
Total Learning Hours: 150
Assessment
- EXAMINATION weighted at 100%
Module Details
INDICATIVE CONTENT
This module is designed to allow you to critically engage with the literature in order to understand the underpinning aspects of drug formulation and delivery needed to deliver the correct dose at the correct site for the correct time to maximise therapeutic impact.
Early sections of the course will interact with material designed to provide the fundamental pharmacokinetic and pharmacodynamics principles necessary for understanding the biological principles involved in designing drugs for optimal therapeutic delivery. This biological material will be linked to basic physio-chemical principles underlying drug formulation and delivery.
Appropriate strategies for large scale production of biopharmaceuticals and biologics will be evaluated and comparisons will be made between the use of prokaryotic, viral and eukaryotic systems. Additionally, the recovery of the end products will be considered along with post fermentation modifications.
The course will also explore the various routes of drug delivery and the strategies utilised to optimise delivery. Formulation will be discussed to address how the product is prepared for therapeutic use, including how to maintain stability of the active component and chemicals used for preservation. Formulation will also extend to a brief overview of appropriate packaging.
Building upon the underpinning materials a range of topics will be covered and include areas such as macromolecular drug carriers, liposomes, micelles, gels, implants, radiopharmaceuticals, microparticles, nanoemulsions, nanoparticles, plastic matrices; soluble and bioerodable polymers. These areas will be supplement by also exploring the classic delivery routes including oral, ocular, transmucosal, transdermal, pulmonary and nasal as well as exploring modern methods of delivery to the CNS.
Early sections of the course will interact with material designed to provide the fundamental pharmacokinetic and pharmacodynamics principles necessary for understanding the biological principles involved in designing drugs for optimal therapeutic delivery. This biological material will be linked to basic physio-chemical principles underlying drug formulation and delivery.
Appropriate strategies for large scale production of biopharmaceuticals and biologics will be evaluated and comparisons will be made between the use of prokaryotic, viral and eukaryotic systems. Additionally, the recovery of the end products will be considered along with post fermentation modifications.
The course will also explore the various routes of drug delivery and the strategies utilised to optimise delivery. Formulation will be discussed to address how the product is prepared for therapeutic use, including how to maintain stability of the active component and chemicals used for preservation. Formulation will also extend to a brief overview of appropriate packaging.
Building upon the underpinning materials a range of topics will be covered and include areas such as macromolecular drug carriers, liposomes, micelles, gels, implants, radiopharmaceuticals, microparticles, nanoemulsions, nanoparticles, plastic matrices; soluble and bioerodable polymers. These areas will be supplement by also exploring the classic delivery routes including oral, ocular, transmucosal, transdermal, pulmonary and nasal as well as exploring modern methods of delivery to the CNS.
ADDITIONAL ASSESSMENT DETAILS
[FINAL] Examination – 2 hrs part seen (100%). Comprising: Section A: One seen question based upon a negotiated topic. Section B: Questions designed to test overall knowledge of the learning material. [Learning Outcomes 1, 2, 3]
A "seen essay plan" exercise within the module will allow direct formative input from the tutor/peers to the specific question being asked upon the examination.
A "seen essay plan" exercise within the module will allow direct formative input from the tutor/peers to the specific question being asked upon the examination.
REFERRING TO TEXTS
Taylor & Aulton (Eds.) (2013). Aulton's Pharmaceutics: The Design and Manufacture of Medicines. Churchill Livingstone ISBN-10: 0702042900
Rang, Ritter, Flower & Henderson (2015). Rang & Dale's Pharmacology. Churchill Livingstone. ISBN-10: 0702053627
Rang, Ritter, Flower & Henderson (2015). Rang & Dale's Pharmacology. Churchill Livingstone. ISBN-10: 0702053627
ACCESSING RESOURCES
None.
SPECIAL ADMISSIONS REQUIREMENTS
None.
LEARNING OUTCOMES
1. Critically analyse various formulation and technological strategies to enhance and optimize drug delivery through various routes.
APPLICATION, KNOWLEDGE & UNDERSTANDING
2. Critically evaluate the various approaches to sustain and control drug delivery.
LEARNING
3. Analyse and discuss the limitations of drug delivery methods.
ANALYSIS, PROBLEM SOLVING
APPLICATION, KNOWLEDGE & UNDERSTANDING
2. Critically evaluate the various approaches to sustain and control drug delivery.
LEARNING
3. Analyse and discuss the limitations of drug delivery methods.
ANALYSIS, PROBLEM SOLVING
Learning Strategies
"This module will contain tutor lead sessions designed to elucidate, explain and help understand the indicative content.
Directed independent research focused and problem-solving/tasks, to include distributed learning material, guided reading and completion of assessment tasks will occupy the remainder of the time.
"
Directed independent research focused and problem-solving/tasks, to include distributed learning material, guided reading and completion of assessment tasks will occupy the remainder of the time.
"