1. On completion of this module you will be able to explain the processes involved in the development and resolution of an immune response. You will be able to describe how modulating these responses can be used to in the treatment of disease.
Knowledge and Understanding
Learning
Analysis

2. On completion of this module you will be able discuss the role of clinical immunology departments in the diagnosis and management of conditions affecting the immune system. You will be able to outline the role of basic and translational research and how this relates to the role of health care scientists.
Knowledge and Understanding
Learning
Analysis

3. On completion of this module you will be able to evaluate the current and future potential of immunotherapies in the treatment of disease and demonstrate the importance of being able to communicate this to the general public.
Knowledge and Understanding
Learning
Analysis

4. On completion of this module you will be able to recognise the importance of being able to articulate complex mechanisms, processes and therapies to a lay audience through public engagement events. Analysis
Problem Solving
Communication
Application
Reflection

1. Grant Proposal 40 % 1500 words
2. Impact of Immunology VIVA 60 % 20 minutes

Grant Proposal – Learning Outcomes 1, 3 and 4
In small groups students will prepare a public engagement grant proposal based on explaining a chosen immunotherapy to the general public. Each student will also produce a short scientific overview explaining the mechanism by which the chosen immunotherapy works. This will include reference to specific cellular and molecular processes. The total assignment will be 1500 words in length.

Impact of Immunology VIVA – Learning Outcomes 1, 2, 3 and 4
Students will have an individual VIVA lasting approximately 20 minutes. The grant proposal will be used as a starting point and questions will be directed to ensure assessment of all of the LO’s. Students will need to be able to articulate the mechanism of action of the immunotherapy, how it would modulate the immune system and the roles of basic and translational research in the development of the therapy. Students would be expected to consider how the work of clinical immunologists are involved in the process of therapy development, diagnosis and management.

In this module you will study how the immune response develops and resolves, focussing on the activation and functional diversity of T and B cell responses - including T helper cell differentiation and regulatory T cell function. The cellular requirements, molecules and associated signalling pathways, required for each of these processes will be covered. Following on from this we will discuss how these processes can be modulated to aid in the control of disease.

You will go on to understand the role of clinical immunology departments in the diagnosis and management of conditions affecting the immune system. The importance of basic and translational research, and how these fit into the remit of HCS, will be examined.

The history, development and current diversity of immunotherapy treatments will be discussed. Their impact on patient outcomes, both actual and potential, will be considered. Biologics such as monoclonal antibody therapies, antibody-drug conjugates, CAR T cell therapy, vaccines, and cytokine therapy are examples of the immunotherapies that could be covered. Elements of design and development, clinical trials, funding and the relationship to personalised medicine will be covered. The influence of genomics on the development and impact of cancer immunotherapies will be considered.

A 'patient first' approach will be taken throughout the module considering the importance of being able to convey complex mechanisms, processes and therapies to a lay audience.

Immunotherapies are new and innovative, offering great promise if we can ensure efficacy and safety. In this module you will learn about the very latest developments in Medical Immunology including how our greater understanding is being used by enterprising individuals and industry to develop new and exciting medicines and treatments.

The module will comprise of seminars, guest lectures, small group tasks and interactive workshops.