This module will enable students to develop and deepen their understanding of the principles and applications of molecular genetics in medicine, with a focus on current technologies and their impact on human health and disease. Indicative content includes:

Introduction to Module: Orientation to module structure, learning outcomes, and assessment strategies.

Molecular Pathology of Genes: Exploration of gene function, dysfunction, and their roles in human disease.

Identifying & Mapping Human Genomes: Techniques for genome identification, mapping, and analysis.

Genetic Manipulation in Mammalian Cells: Methods and applications of genetic modification in mammalian systems.

Polymerase Chain Reaction (PCR) and Restriction Enzymes: Principles and laboratory application of key molecular biology techniques.

DNA Sequencing Technology: Overview of sequencing methods and their relevance to medical genetics.

Deep Sequencing of Whole Genomes: Advanced strategies for high-resolution genome analysis.

Genome Editing: Methods and Applications: State-of-the-art genome editing tools and their use in medicine.

Integrating ‘Omics’ and Systems Biology: Systems biology approaches and integration of multi-omics data in molecular genetics and genetic engineering.

Genomics and Personalized Medicine: Utilization of genomic information in personalized medical strategies and patient care.

1) The end point exam assessment is composed of detailed description and interpretation of molecular genetic diagrams, short answer questions, and a reflective essay question addressing LO1, LO2, LO3. Assessment questions will be based on genetic disorders and the application of molecular genetics knowledge and skills to diagnosis, prognosis and management strategies. The examination will also require students to demonstrate critical reasoning through the evaluation of complex genetic data and the justification of diagnostic or management decisions based on the evidence presented.

Formative Assessment

Formative assessment activities are designed to enhance students’ critical understanding and reflection on molecular genetics in medicine.

Self-Assessment and Feedback: Students will self-assess their work using model answers and receive structured feedback to reinforce their knowledge, understanding, critical reasoning and collaboration and Digital Literacy.

Online Formative Quiz: An online quiz, reflecting the format of the final exam, will include questions on the application of genomics, systems biology, and personalized medicine for the prevention, diagnosis, and treatment of disease. Results will be discussed in class to encourage reflection and address misconceptions.

Formative assessments directly support both learning outcomes by fostering critical understanding, analysis, and reflective skills related to molecular genetics, health, and disease.

Summative Assessment

The summative assessment evaluates students’ ability to apply and reflect on the integration of molecular genetics in medicine:

Format: 2-hour end point assessment.

Content: The exam will feature diagram explanations, short answer questions, and a reflective essay question addressing genetic disorders and the use of molecular genetics techniques—including genome mapping, genetic manipulation, and DNA sequencing—in diagnosis and management.

Focus: Students will analyse and reflect on the integration of genomics, systems biology, and personalized medicine, and consider ethical, legal, and social implications in relation to human disease.

The summative exam is mapped to LO1, LO2 & LO3, assessing students’ critical understanding, application, analysis, and reflective skills in molecular genetics as applied to health and disease.

The learning strategy for this module centres on engaging, interactive face-to-face lectures, supplemented by seminars, workshops, and in-class formative tasks to create a dynamic and supportive learning environment.
Lectures provide a structured exploration of core molecular genetics topics, including molecular pathology, genome mapping, genetic manipulation, and DNA sequencing. These sessions encourage understanding through discussion, questioning, and collaborative activities, enabling students to investigate complex genetic concepts and their relevance to health and disease.
Seminars and workshops offer opportunities for deeper engagement with the material, promoting analysis, problem solving, and application of molecular genetics to real-world clinical scenarios. Students participate in group discussions, case studies, and data interpretation exercises, developing critical thinking and communication skills.
In-class formative tasks are integrated throughout the module to reinforce key principles, encourage reflection, and provide immediate feedback. These activities support the development of analytical and reflective skills, ensuring students can connect theory with practice and address areas for improvement. Directed independent study, including recommended readings and assessment preparation, further supports learning and fosters self-management skills. Tutorials and student-led activities encourage collaboration, peer learning, and provide opportunities to clarify complex topics with academic staff.
Continuous feedback is provided during lectures, seminars, and workshops, helping students to monitor their progress and consolidate their understanding. Summative assessments challenge students to demonstrate both theoretical knowledge and its application, preparing them for advanced study or professional practice in molecular medicine.

1. Critically apply advanced molecular genetics techniques including genome mapping, high-throughput sequencing, genetic manipulation, and genome editing to analyse complex human diseases and evaluate their implications for personalised medicine

Knowledge & Understanding, Application & Problem Solving.

2. Integrate and evaluate multi-omics and systems biology data to develop evidence-based strategies for the prevention, diagnosis, and management of genetic diseases, with consideration of ethical, legal, and social implications in clinical practice.

Research Skills, Digital Literacy.

3. Interpret, synthesize, and communicate complex genomic and genetic information (including deep sequencing results and multi-layered data) to diagnose genetic disorders and formulate comprehensive management plans, demonstrating advanced problem-solving and decision-making skills in a medical genetics context.

Critical Reasoning & Collaboration, Communication.

Students will require access to a suitable PC with reliable internet connectivity and essential software, including Office 365 (MS Teams, OneDrive, Word, and PowerPoint). Core reading materials and scientific literature will be accessible through the University of Staffordshire library resource page and online learning platforms. Regular use of the university’s Blackboard system and other digital resources will be necessary for participation in module activities, seminars, workshops, and assessments.

Essential Reading
Pierce, B. – Genetics, 7th Edition (2020), MacMillan Learning. ISBN: 9781319325466 (Primary textbook covering fundamental principles relevant to the module)
Griffiths, A.J.F., et al. – Introduction to Genetic Analysis, 12th Edition (2020), W.H. Freeman. ISBN: 9781319114787 (Comprehensive coverage of genetic analysis and its applications)
Recent E-Journal Articles: Current research articles and reviews from e-journals, accessible via the University Library and online sources.
Turnpenny, P.D. & Ellard, S. – Emery's Elements of Medical Genetics, 16th Edition (2022), Elsevier. ISBN: 9780702082318 (Essential reference for medical genetics with clinical context)

Recommended Reading

Varshney, R., Pandey, M., Chitikineni, A. – Plant Genetics and Molecular Biology (2018), Springer. ISBN: 9783319913131
Henkin, T. – Molecular Genetics of Bacteria, 5th Edition (2020), Wiley and Sons. ISBN: 9781555819750
Lohstroh, P. – Molecular and Cellular Biology of Viruses (2019), Routledge. ISBN: 9780815345237

This module provides an in-depth examination of molecular genetics in the context of human health and disease. You will study the molecular pathology of genes, explore advanced techniques for genome mapping and genetic manipulation in mammalian systems, and delve into the principles and applications of DNA sequencing, including PCR, deep sequencing, and genome editing. Through a combination of interactive lectures, seminars and workshop activities, and data analysis tasks, you will develop the skills to apply molecular genetics knowledge to the diagnosis, management, and prevention of disease. The module also covers the integration of systems biology and ‘omics’ technologies in personalised medicine, enabling you to interpret complex genetic data and reflect on the ethical, legal, and social implications of genetic technologies in healthcare. By engaging with real-world case studies and reflective exercises, you will learn to critically evaluate current research, understand molecular mechanisms in medicine, and communicate your insights effectively preparing you for further study or professional practice in this rapidly advancing field.